An Elucidation of Neutrophil Functions against Mycobacterium tuberculosis Infection.

Published: Dec, 2013 in the Journal Clinical and Developmental Immunology

The study looks at cells taken from functionally normal individuals and shows that liposomal glutathione improves the ability of neutrophils to control intracellular Mycobacterium tuberculosis (M. tb) infection. In addition, the study shows that liposomal glutathione decreases formation of free radicals in cells that are undergoing infection and goes into detail about the mechanisms that control infection with M. tb and shows how these mechanisms are supported by supplying the whole molecule of glutathione, as occurs with liposomal glutathione and not by a precursor amino acid.

In this study, we investigated the effects of GSH in enhancing the innate and adaptive immune functions of DCs against Mycobacterium tuberculosis (M. tb) infection. We also characterized the functions of the sub-populations of CD4+T cells such as Tregs and non-Tregs in modulating the ability of monocytes to control the intracellular M. tb infection. Our results indicate that GSH by its direct antimycobacterial activity inhibits the growth of intracellular M.

PMID: 24312131

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